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to failure to initiate or respond to social interactions

These effects are transient in most people but can be clinically significant in those with underlying hypertension or conduction abnormalities

Common signs include: Fatigue and weakness Numbness or tingling in the hands and feet Difficulty walking or balance problems Mood changes, such as depression or anxiety Cognitive difficulties, including memory loss or confusion If not treated, a B12 deficiency can cause serious problems

Isoproterenol produced a similar contractile response with no change in basal calcium