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Results from another uncontrolled intervention in 21 HIV-positive patients suggested that long-term (two to four years) oral ALCAR supplementation (1.5 g/day) may be a beneficial adjunct to antiretroviral therapy to improve neuropathic symptoms in some HIV-infected individuals (80, 81)

So far, six patients with clEDS and tissue fragility have been reported in the literature, predominantly but not exclusively of the gastrointestinal tract: (1) perforation of colonic diverticulum, development of multiple abscesses requiring partial colectomy, complicated by second small bowel perforation in a 36-year-old man

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Incorporating stress management techniques, such as meditation or yoga, can be beneficial