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While a dominant-negative effect might have been anticipated, heterozygous mice are normal, while homozygous mice have severe defects of cornea, mildly impaired growth, skin fragility, and mild skin extensibility a substantially different phenotype from classical EDS due to COL5A1 haploinsufficiency

Vitamin B12 also interacts closely with neurotransmitters within the brain and appears beneficial in Autism

The addition of high dose niacin was intended to increase HDL ("good") cholesterol, reduce elevated triglycerides, and, most importantly, reduce the risk of heart attacks and stoke

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Nevertheless, chemical interactions on the scalp surface could occur

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