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Based on evidence-based guidelines for the diagnosis and treatment of gouty arthritis, the present review suggests the use of flavonoids in symptomatic treatment according to the stages of gout: During gouty arthritis attacks, flavonoids manage oxidative stress and inflammatory signaling pathways to exert anti-inflammatory effects, while in stages of asymptomatic hyperuricemia, intermittent gouty arthritis and chronic gouty arthritis, flavonoids inhibit UA synthase activity and regulate UA transporter expression to reduce serum UA levels (101)

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they can also transport 5-HT from adjacent cells or CSF to hippocampal neurons