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Linked NAD(H) - ATP Pathways Importance of the NAD + to NADH Ratio + to NADH Ratio One of the insights arising from the scientific studies of calorie restriction is that the ratio of NAD + to NADH (NAD + : NADH ratio) might be important for the lifespan extension benefits

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Two estimands were employed: the trial product estimand, which evaluated treatment effects assuming perfect adherence to the assigned regimen, and the treatment policy estimand, which included all randomized participants regardless of adherence

Footnotes Authors Contributions: GL, LH, and ZZ wrote the manuscript