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This Research Topic is part of a series with: The changing faces of glutathione, a cellular protagonist., Volume II Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases

Available as an injection and, more recently, as a spray to be inhaled and delivered via the noses mucus membrane, today it is used (against better judgement) to stimulate the production of melanin within the skin to produce a deeper and faster tan

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We have previously shown that adenosine A1AR and A2AR of HSCs promote the activation and proliferation of HSCs after activation under the action of acetaldehyde

4.3 Glutamine Glutamine (Gln) is mainly converted through GLS/glutamate dehydrogenase (GLUD)-related reactions to generate -KG, which enters the TCA cycle and provides anaplerotic substrates for oxidative metabolism, while also influencing polarization-related epigenetic regulatory processes through metabolic ratios such as -KG/succinate (58)

Xing X, Dan Y, Xu Z, Xiang L