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Figure 3 As mentioned previously, GSH, a tripeptide containing glutamate, cysteine and glycine, (L--glutamyl-L-cysteinyl-glycine) is the master and most potent cellular antioxidant and the most abundant low molecular weight thiol that plays a crucial role in antioxidant defense against cellular ROS/reactive nitrogen species (RNS)-mediated oxidative damage and in the regulation of numerous metabolic pathways essential for maintaining whole body homeostasis

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Generally, the prevalence of DPN in patients with DM ranges from nearly 20% to over 70% in different countries and regions, where studies in China reported the highest prevalence of DPN in patients with DM, suggesting the urgent demands for proper management of DPN in patients with DM, especially patients in China

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