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Clinicians using epitalon rely on extrapolation from animal data and observational reporting not clinical trial dose-finding

Those that are will face a market where, unlike small-molecule generics, pricing erosion will be gradual rather than immediate originator pembrolizumab will likely maintain 50 to 70 percent of list price for several years after biosimilar entry, based on patterns from adalimumab biosimilar uptake

doi: 10.1016/j.arr.2019.100946 27

Second, a large percentage of patients had multiple reasons for discontinuation in their notes

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