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Additionally, GPX4 degradation via chaperone-mediated autophagy is another approach to induce ferroptosis (38) ( Figure 1 )

Neuron 52 : 577585

The catalytic cycle of GPx includes a peroxidatic part that is followed by a reductive step (Figure 4) [47]

In: Le, A

The importance of SOD becomes evident when examining its evolutionary conservation across species, from bacteria to humans, indicating its fundamental role in protecting aerobic life from oxygen toxicity