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When immune cells adopt a proinflammatory metabolic phenotype, for example M1-dominant macrophages, elevated ROS production and disrupted iron homeostasis often predispose both these cells and surrounding tissues to ferroptosis

I.WilkinsonS.HahnM.TasdemirN.OPreyJ.ClarkW.et al (2017)

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6B), we measured serum AST and ALT levels in the early stage post-APAP administration to evaluate protection against 600 mg/kg APAP-induced hepatotoxicity

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