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Although only certain isomers of -tocopherol are retained in the circulation, all forms are absorbed and metabolized by the liver

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Grant, and J

Instead, research points to activity across multiple interconnected systems, including modulation of the nitric oxide (NO) system, upregulation of growth factor expression (notably VEGF, EGF, and FGF pathways), promotion of angiogenesis, and activation of the FAK-paxillin signalling pathway involved in cell migration and tissue organisation

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