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Taken together, our results provide additional insights into antibody-based targeting of class A GPCRs, and give a detailed molecular description of the mechanisms underlying CCR8 activation by CCL1, providing a structure-function framework that might facilitate the development of future antibody therapeutics targeting chemokine receptors in particular and more broadly, class A GPCRs

Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation

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Nrf2 was found to participate in transcriptional activation of antioxidant enzymes that act as a cell defensive system to detoxify NAPQI (Goldring et al., 2004)

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