In silica-induced fibrosis models, blocking glycolysis or HIF-1 signaling reduces intracellular glycine levels, which correlates with decreased collagen deposition and attenuated fibrotic responses [110]
In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration
The liver converts fat-soluble toxins into water-soluble ones for elimination
Proper peptide handling and storage may help reduce degradation pathways such as hydrolysis, oxidation, or structural destabilization during experimental use
Cell Death Differ 25:6580 Qian S, Wei Z, Yang W, Huang J, Yang Y, Wang J (2022) The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
Plain language summary Men and women often develop different co-occurring health conditions, but the biological reasons are not well understood
