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8 Data from a phase 2 trial of 338 adults with obesity without diabetes suggests substantial weight loss benefit with retatrutide, with 26% of participants having a body weight reduction of 30% with the highest dose of retatrutide (12 mg SC once weekly)
ATB 0,+ is able to transport carnitine with low affinity when OCTN2 activity is limited [173]
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Intermediate risks were observed for exenatide (0.048%), dulaglutide (0.047%), liraglutide (0.055%), and lixisenatide (0.073%)
In the cardiovascular field, there are analyses of trials that suggest benefits for some outcomes, but it is unclear how much these translate to modern practice with current therapies