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Mice were euthanized after a 6 h fast by carbon dioxide asphyxiation and blood was drawn by cardiac puncture

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By means of dimethylated histone H3 K79, DOTL1 facilitates histone H4 acetylation, consequently regulating the binding of BRD4 to chromatin Moreover, inhibition of BRD4 activity was found to suppress proliferation in the majority of patients with chronic phase CML