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Future Med Chem 6(15):167798

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Dynamics and line broadening: rapid conformational fluctuations within IDPs/IDRs, particularly on the millisecond to microsecond timescale, can lead to significant line broadening in NMR spectra, sometimes preventing direct studies of partially folded intermediates like molten globules

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paper introduced Dihexa as a metabolically stabilized AngIV analogue and reported reversal of scopolamine-induced spatial learning deficits in rats and improved spatial learning in aged rats following oral administration

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