The speed and extent of regain vary significantly between individualssome patients stabilize losses
Rats were fed diets containing upto 50,000 ppm LC for 90 days, followed by a 4 weeks recovery phase, in a 90-day subchronic investigation
For many, this means losing significant muscle mass and becoming colloquially known as skinny fat. In other words, there may be considerable weight loss, but the patient may not be burning enough of the bad visceral or white fat and instead are losing muscle, which can lead to skeletal issues, like osteoporosis, in the future
PMID: 67 ZierkeLJohnDGischkeMTranQTSendlerMWeissFUet al
For example, ROS can activate nuclear factor kappa B (NF-B), a key transcription factor that regulates the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules [134]
This mechanism explains why some patients report feeling less bloated and experiencing fewer late-night heartburn episodes, independent of appetite suppression