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Preclinical studies have demonstrated that MSC-Exo lack major histocompatibility complex -related antigens on their surface, resulting in minimal immunogenicity and enabling cross-species and cross-individual applications, while they can also modulate the functions of immune cells such as macrophages and T cells, inhibit aberrant inflammatory responses, further enhance immunocompatibility, and reduce the risk of rejection (Zhang et al., 2022

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