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[2] The concept behind transdermal GLP-1 delivery involves using a patch applied to the skin that would theoretically release medication through the dermal layers into systemic circulation

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The slowed gastric emptying reduces the rate at which stomach contents move into the small intestine, which lowers postprandial glucose peaks but can increase sensations of early satiety, bloating, and nausea

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issues: This can include nausea, vomiting, stomach cramps, bloating, constipation, and diarrhea

[] Additionally, GLP-2 and GIP both minimize bone resorption in humans, [] but the molecular mechanism involved is poorly understood