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Critical safety considerations for laboratory use include potential immunogenicity concernswith peptide therapeutics commonly showing injection site reactions (20-40% with subcutaneous administration) and possible antidrug antibody formationalong with theoretical concerns that pro-angiogenic properties could potentially influence experimental tumor models, requiring appropriate controls in oncology-related research

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But losing 10-15% to freeze damage may be preferable to losing 70% to expiration at room temperature or refrigeration beyond 30 days

While small-scale studies are ongoing, the transition to adequately powered trials with comparison groups remains a research priority for advancing regulatory policy and understanding

These peptides often have multiple mechanisms of action, making it more difficult for bacteria to develop resistance