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FEBS Lett 437(1-2): 145-148

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However, native GLP-1 has a limited half-life (1.55 min) due to its degradation by the enzyme Dipeptidyl peptidase 4 (DPP-4), necessitating the development of GLP-1 receptor agonists (GLP-1RAs) with longer activity (Campbell and Drucker 2013)

Specifically, liraglutide did not induce ROS or increase PTX3 (an inflammatory signal) expression in endothelial cells in one study, 69 and in fact, it attenuated the increases in both ROS and PTX3 induced by TNF- , suggesting it was not increasing inflammatory activity

However, long-term safety remains unproven

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