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The authors findings were likely due to the small rises in NO observed in these studies, as they were not significantly different to the placebo (CM: 15.3 1.1

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Given that we have established selenoproteins such as GPx3 and SELENOP to be substantially reduced in those affected with disease using multiple applications and cohorts, perhaps a reduction in the ability to effectively manage oxidative damage is a leading factor for disease susceptibility and severity, when all other risk factors have been met, which are typically present even in those without konzo

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