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Statistical analysis was performed by t -test (unpaired or paired, as indicated), one-way analysis of variance (ANOVA), two-way ANOVA (time treatment or genotype treatment) with post hoc comparisons (where appropriate, as indicated in the figure legends)

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PSM incorporated demographic factors (age, sex, race, ethnicity), comorbidities (hypertension, dyslipidemia, cardiovascular disease), medications (antihypertensives, lipid-lowering agents, antidiabetics), laboratory parameters (HbA1c, lipid profile), and BMI (Supplementary Data 2)