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Reprod Toxicol 26:1923

Some patients experience rapid sleep onset improvement while others notice gradual progressive enhancement of deep sleep quality

[13] [15] The frequency and severity of side effects are influenced by the dose, route of administration, and individual patient factors

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For example, TPD uses an event-driven, catalytic mechanism, allowing the compounds to bind anywhere on their target protein, bind less potently than traditional inhibitors, and be used at sub-stoichiometric levels

A total of 23 patients (16.7%) reported adverse events, including insomnia, shivering, headaches, and nausea