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He also noted shortcomings of the trial, including that the study group and duration was small, with only 82 children taking the drug or a placebo for 56 weeks

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120 In addition, hepatic glucose lead to a deficiency in the transcription factor carbohydrate responsive element binding protein (ChREBP) resulting in reduced mRNA levels of glycolytic and lipogenic enzymes, as well as SREBP-1c levels

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Blood flow increases, fibroblasts migrate in, collagen gets laid down