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During the 1970s the pharmaceutical company Glaxo has poured a lot of investment into the development of CCK because it had been shown to suppress appetite in rodents

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[7] demonstrated that increased renal ammoniagenesis may be the primary cause of hyperammonemia in GDH-HI patients

10.1038/nature11986 117 ThomasC.MackeyM

They were seen as a way to control the rapid growth in behavioral health spending that occurred in the 1980s, when states loosened regulatory controls and the number of psychiatric inpatient facilities ballooned

The intensity and type of side effects can vary, and not everyone will experience them