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GIP receptor activation: increases energy expenditure, improves insulin sensitivity and may reduce food intake

Biesalski, H.K

S.ChamariM.ZeleznikO

Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase

It is challenging to identify such candidate drugs from the existing literature, since only a limited number have been experimentally tested for their action on POMC neurons in animal models

Retatrutide is an investigational triple agonist of GIP, GLP-1, and glucagon receptors developed by Eli Lilly