ATR-107 is a fully human anti-IL21 receptor antibody that generated a high degree of ADA with adverse events associated with hypersensitivity reactions during clinical investigation 23
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These limitations underscore the need for novel therapeutics that target more upstream pathways in UC pathogenesis
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Targeting mitochondria in therapy: toxicity, mechanistic ambiguities, and translational barriers Although mitochondrial-targeted therapies have shown great potential in various cancers, they still face significant challenges in clinical advancement
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