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65% of patients in the combnation form lost 15% weight (compared to 38% in the monotherapy form and 0% in the placebo form)

Safety, Side Effects, and Long-Term Considerations of Semaglutide The most commonly reported side effects of semaglutide are gastrointestinal: nausea, vomiting, diarrhea, and constipation, typically appearing during dose escalation and diminishing after two to four weeks

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doi: 10.3389/fphar.2025.1551843

Hypothalamic effector neurons and extended circuitries activated in neurogenic stress: a comparison of footshock effects exerted acutely, chronically, and in animals with controlled glucocorticoid levels