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The 2,2-dimethyl-tetrahydropyran moiety inserts between TM2 and TM3, forming hydrophobic contacts with aliphatic and aromatic residues lining this inter-helical space

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This observation suggests that GHK-Cu can enhance resilience to brain aging, and has translational implications for further testing in both preclinical and clinical studies using an atomizer device for intranasal delivery

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