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A commonly used ADC linker makes use of a valine-citrulline (vc) dipeptide, first discovered by Dubowchik et al., as an intracellular cleavage mechanism by cathepsin B

Gamma-glutamyl transpeptidase deficiency leads to glutathionuria, glutathionemia, growth failure, cataracts, lethargy, shortened life span, and infertility

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This could be the result of a matrix-related effect, as serum components may interfere by reducing the recovery of the target analyte (Supplementary Tables S2 and S3)

ZNT5-6 and ZNT7 play an integral role in protein N-glycosylation by supplying Zn 2+