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Hu Z, Cha SH, Chohnan S, Lane MD

It can eventually lead to an intestinal obstruction, which may require surgery to resolve

Its discovery originated from studies comparing human plasma from young and older adults, with the younger plasma being more effective in inducing macromolecular synthesis in rat hepatocytes and hepatoma cells [8, 9]

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The dual agonism is what differentiates it from semaglutide, which targets GLP-1 alone