Abstract Severe cutaneous adverse reactions (SCARs), which include StevensJohnson syndrome and toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (also known as drug-induced hypersensitivity syndrome), acute generalized exanthematous pustulosis, and generalized bullous fixed drug eruption, are life-threatening conditions
The global market for these medications is growing rapidly
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McIntosh, Keith, et al
Patients commonly report profound dysphagia (difficulty swallowing subsequent liquids or saliva) and odynophagia (sharp, stinging pain upon swallowing), directly related to the mucosal burn and muscular spasm
Research also points to DSIP influencing stress-related metabolic disturbances that shift mitochondrial respiration from oxygen-dependent to oxygen-independent pathways