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Of these, the mean difference between GLP-1 based therapies and controls in the percent changes from baseline were: 40.16 [51.50, 28.81] %

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Although SGLT-2 inhibitors and GLP-1 receptor agonists do not increase the risk of severe hypoglycemia, SGLT-2 inhibitors increase the risk of genital infections, and GLP-1 agonists have gastrointestinal adverse effects, especially at initiation and with high doses