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doi:10.1359/JBMR.041018

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However, an early deviation in the slope suggested a violation of the proportional hazards assumption in the first 12 months, although the stabilization afterward indicated the issue was not persistent over the full duration of the study

Specifically, we suggest that the benzyl portion of the isobenzopyrrole-1,3-dione moiety of CP17 might be modified to provide groups able to make polar or charge interactions with the carbonyl oxygen of VP1-Ile89 or the carboxylate of the sidechain of VP1 Asp114 (Fig

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