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Combination therapies: Orforglipron could be combined with other oral agents (e.g., oral GIP agonists, SGLT-2 inhibitors, phentermine) for enhanced efficacy, or formulated as a fixed-dose combination tablet
Many experts consider maintaining a 5-10% weight loss from baseline as clinically successful, given the significant health benefits this provides
Examples: 16-year-old boy: BMI 27.5 (24.2 is 85th percentile) 16-year-old girl: BMI 29 (24.5 is 85th percentile) 17-year-old boy: BMI 28.4 (25.0 is 85th percentile) 17-year-old girl: BMI 29.5 (25.1 is 85th percentile) Exclusion or Contraindications GLP-1 therapy is not recommended for teens with: A personal or family history of medullary thyroid carcinoma or MEN2 A history of pancreatitis Severe gastrointestinal disease , such as gastroparesis or inflammatory bowel disease flare Current pregnancy or planning pregnancy Active eating disorder or untreated major psychiatric illness If your teen has any of these conditions, our providers will guide you toward safer, more appropriate options
Therefore, when using GLP-1 receptor agonists, it is essential to assess individual patient differences and select appropriate treatment strategies accordingly
