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If we were to construct a plot of GH concentration versus time of day (in hours) from data on young and old individuals, we would see that the amplitude and frequency of GH pulses are highest during youth, but decline steadily with age, as shown below: Figure 2: GH Pulse Amplitude and Frequency Decline with Age Research indicates that a reduction in GHRH secretion from the hypothalamus is the principal cause of diminished GH production with age

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