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Para embarazo planificado, algunos agentes como semaglutida deben suspenderse al menos 2 meses antes de la concepcin planificada [15] [17] Diagnstico de carcinoma medular de tiroides o MEN-2: Contraindicacin para agonistas GLP-1 con advertencia en caja (semaglutida, liraglutida, dulaglutida) [18] [19] Situaciones que justifican cambio de agente: La intolerancia gastrointestinal persistente tras 12 semanas de tratamiento puede justificar cambio a un agonista GLP-1 alternativo con diferente perfil farmacocintico

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Regulatory guidance for orally administered drugs typically requires that the 90% confidence intervals for key pharmacokinetic parameters (Cmax and AUC) fall within predefined limits, commonly 80%125% of a reference product (Rowland and Tozer, 2011)

The Newcastle Ottawa Scale [53] for case control studies was modified to assess the methodological quality of observational articles for the review (Table 1)