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In turn, NHE1 promotes cell volume expansion, which increases membrane tension, resulting in TRPV4-mediated calcium influx and the activation of actomyosin contractility [161]

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6.4 Summary of RCTs In the RIPENACTB trial, adjunct NAC treatment with 1,200 mg twice a day in hospitalized HIV/TB patients significantly reduced circulating lipid peroxidation (malondialdehyde (MDA) levels by approximately 40%50%) and increased antioxidant defenses, including glutathione (GSH, by approximately 30%40%), compared to baseline and the standard care group

La dosis tpica es de 1 tableta al da, preferentemente con una comida