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Additionally, Ex-4 has been demonstrated to reduce extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinases (MAPK) phosphorylation in LNCaP prostate cancer cells [17]

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The maximum recommended maintenance dose is 15 mg once weekly

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Polycystin-2 is an intracellular calcium release channel

Practical guidance on intravenous dosing, continuous infusion, and titration in special populations such as obstetric and perioperative patients is provided