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FIGURE 3 The first choline-TMA lyase inhibitor, DMB, was identified by Wang and colleagues, which is shown to non-lethally inhibit distinct microbial TMA lyases, and reduce TMAO levels in mice fed a high-choline or L-carnitine diet (Wang et al., 2015)

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Additionally, metformin affects glioma stem cells by inhibiting key pathways, including STAT3, mTOR, and AKT, and altering the tumor microenvironment

Conversely, TP53 can inhibit ferroptosis in certain conditions

OLK is one common type of OPMDs whose overall malignant transformation rate is estimated to be 3.5% (Aguirre-Urizar et al., 2021)

Finally, we conducted a correlation between the gut microbiota and striatal metabolites