J Headache Pain 26 , 46 (2025)
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The decision to start semaglutide GLP-1 weight loss treatment will be made jointly between the patient and our healthcare team, ensuring it aligns with the individuals health goals and medical needs
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The underlying mechanisms have not been fully delineated but are likely to involve modulation of the brain dopamine reward system via GLP-1 receptors, which are present both in the ventral tegmental areas (VTA), where dopamine neurons are located, and in the nucleus accumbens (NAc), which is the main projection of VTA dopamine neurons 14
