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According to findings from the National Institute of Mental Health's Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), two-thirds of patients with bipolar I or II depressive syndromes have concomitant manic symptoms, typically distractibility, flight of ideas or racing thoughts and psychomotor agitation [28]

Exposure to e-cigarettes containing nicotine or flavorings leads to increased production of ROS, reduced NO bioavailability and endothelial cell apoptosis, resulting in endothelial dysfunction, which in turn leads to insufficient angiogenesis and impaired diabetes wound healing (Fig

10.1016/s0306-4522(96)00434-4 41 LeachL

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