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Similarly, targeting NRF2 to upregulate phosphorylase kinase catalytic subunit 2 promotes ferritinophagy and mitochondrial stress-dependent ferroptosis, increasing radiosensitivity (123)

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Jack Khattar, president & CEO of Supernus, said the company remain[s] committed to bringing SPN-830 to the market and will work with the FDA to address the issues identified in the CRL and resubmit the NDA

Consequently, multi-target ferroptosis modulators and nanomaterial technologies have been explored to achieve more effective in vivo targeting of ferroptosis