Inflammation in CD involves the entire gut wall and may occur in any part of gastrointestinal (GI) tract, whereas in UC, only colonic mucosa is affected (Zatorski et al
Orforglipron, an oral GLP-1 receptor agonist for obesity (ATTAIN-1)
A composite of cardiovascular death, nonfatal myocardial infarction (MI), nonfatal stroke, or hospitalization for unstable angina was established as primary cardiovascular outcome
FASEB J 17:9193 Koh EH, Kim MS, Park JY et al (2003) Peroxisome proliferator-activated receptor (PPAR)- activation prevents diabetes in OLETF rats: comparison with PPAR- activation
Similarly, the STEP 5 trial demonstrated even greater results, with participants achieving a mean weight loss of -15.2% after two years (104 weeks)
Most users report mild to moderate appetite reduction and modest weight loss, though it is difficult to separate supplement effects from accompanying lifestyle changes