In small proof-of-concept phase 2 randomized controlled trials (RCTs) in patients with biopsy-confirmed MASH, liraglutide at 1.8 mg/day for 48 weeks (201), semaglutide at 0.4 mg/day for 72 weeks (202), and tirzepatide at 15 mg/week for 52 weeks (203) have been reported to achieve placebo-corrected percentages of participants meeting the criteria for resolution of MASH without worsening fibrosis by 30% (P = 0.019), 42% (P 10%) may lead to diabetes remission (237)
However, there is still a long journey from this first-in-class compound to a safe and effective drug
doi: 10.1042/BST20170503 402 JonesDEHollingsworthKGJakovljevicDGFattakhovaGPairmanJBlamireAMet al
This inconsistency can slow weight loss progress and force dose adjustments that should not be necessary with proper technique
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