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HelmstdterJKeppelerKAustFKsterLFrenisKFilippouKet al
The C-terminal half is stabilized by interactions with the ECD N terminus -helix, TM2 and ECL1, with Y205 2.75b pointing outward to the TM1-TM2 cleft allowing the entrance of ECD
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From a practical standpoint, discontinuation strategies should therefore address not only timing, but also the post-cessation stabilization of body weight and metabolic status during the washout period
Think about it: GLP-1 agonists primarily enhance insulin secretion and suppress glucagon, while Cagrilintide tackles gastric emptying and satiety
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