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FDA Drug Safety Communication: FDA revises warnings regarding use of the diabetes medicine metformin in certain patients with reduced kidney function

Bacteriostatic water adds benzyl alcohol, which lets you use the same vial for about 28 days when refrigerated

There is no requirement to maintain the same concentration across vials

For example, once weekly dosing of tirzepatide (a dual GIPR and GLP-1R co-agonist) has superior efficacy for weight reduction compared to the GLP-1R agonist, semaglutide

According to the FDA, semaglutide and tirzepatide peptides cannot cross the skin barrier effectively per pharmacokinetic studies

A.ParrellaP.DAlessandroV.la TorreA.BarbanoR.FontanaA.et al (2011b)