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18 Similar height responses were shown in 2 randomized trials of rhIGF-1 therapy among patients with growth retardation (although not necessarily with confirmed SPIGFD) 25 , 26 and a case-based study of 2 prepubertal siblings with PAPP-A2 homozygous frameshift gene mutation (an autosomal recessive syndrome consisting of short stature, among other symptoms)

doi: 10.1111/j.1600-079X.2012.01012.x 83 LanoixDOuelletteRVaillancourtC

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