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Nonetheless, the most updated literature reports that -carotene supplementation or elevated blood -carotene levels may increase all-cause mortality and CVD risk [147, 148]

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Acknowledgments This work was supported by the competitive funding of Pirkanmaa hospital district (9E112 and 9D099) to R

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Similar estimates of loss of MOR function between these studies might be interpreted to suggest that tolerance at the level of MOR represents nothing more than desensitization